In neurodegenerative diseases such as Alzheimer’s disease [10, 11], Parkinson’s disease [12], amyotrophic lateral sclerosis [13], and MS [14, 15], dysregulation of this complex can trigger and sustain NLRP3 inflammasome activation and thereby drive CNS neuropathology. This evidence concerns the gene NLRP3 and early-onset autosomal dominant Alzheimer disease.