An exciting and relatable early success of nutrigenomics was the discovery that consuming > 2 cups of coffee per day was associated with increased blood pressure and as much as a 50% increase in myocardial infarction (MI) risk in individuals with the “slow caffeine metabolizer” CYP1A2 genotype (rs2472300) [63]. Here, CYP1A2 is linked to myocardial infarction.