Along with reducing angiotensin II production, ACEIs also reduce arterial stiffness by a decrease of vascular remodelling, improves endothelial dysfunction by increasing the expression of endothelial nitric oxide synthase (eNOS), lowers ROS production by inhibiting NADPH oxidase and has antiatherogenic effects through reduced LDL oxidation [40, 41]. This evidence concerns the gene NOS3 and endothelial dysfunction.