Our research yielded a 10-gene marker model—SLC2A3, MMP11, SCARA3, GPC1, OLFM2, L1CAM, CRABP2, PHGR1, TFF1, and CLCA1—that potentially exert significant roles in the occurrence, progression, and prognosis of CRC. This evidence concerns the gene L1CAM and colorectal carcinoma.