Our research yielded a 10-gene marker model—SLC2A3, MMP11, SCARA3, GPC1, OLFM2, L1CAM, CRABP2, PHGR1, TFF1, and CLCA1—that potentially exert significant roles in the occurrence, progression, and prognosis of CRC. Here, CRABP2 is linked to colorectal carcinoma.