Our research yielded a 10-gene marker model—SLC2A3, MMP11, SCARA3, GPC1, OLFM2, L1CAM, CRABP2, PHGR1, TFF1, and CLCA1—that potentially exert significant roles in the occurrence, progression, and prognosis of CRC. The gene discussed is OLFM2; the disease is colorectal carcinoma.