TCF21 and Myocardial fibrosis: Moreover, a preclinical study in the cardiovascular field revealed the effective suppression of fibroblast-induced fibrogenic differentiation by intrapericardial injection of LNP-encapsulated lncRNA-Tcf21 antisense RNA inducing demethylation (TARID), leading to improved cardiac function and electrophysiological properties in mouse and pig models, establishing the therapeutic potential of LNP-TARID for myocardial fibrosis [218].