GPR27 and gastric cancer: While high TMB group survival analysis showed the same results: GC patients with lower expression of GPR27 exhibited longer OS (HR=1.76, 95%CI:1.08-2.85, P=0.02, Supplementary Figure 2E) and DFS (HR=3.5, 95%CI:1.27-9.61, P=0.01, Supplementary Figure 2F).