Firstly, we analyzed TCGA-STAD cohort and found that GC patients with lower level of GPR27 had a longer OS (HR=1.63, 95%CI:1.13-2.34, P=0.0083, Figure 2A) and DFS (HR=3.12, 95%CI:1.47-6.63, P=0.0018, Figure 2B). Here, GPR27 is linked to gastric cancer.