Pharmacological inhibition of SUR1–TRPM4 with the SUR1 inhibitor glibenclamide reduced brain oedema and associated brain damage in several rat models of ischaemic stroke and TBI (Simard et al., 2012; Simard, Yurovsky et al., 2009; Zweckberger et al., 2014). This evidence concerns the gene ABCC8 and ischemic stroke.