Moreover, the expression of monoamine oxidase B (MAO‐B), a key enzyme for astrocytic GABA synthesis and GABA activity, was reported to be significantly increased in reactive astrocytes in rodent models of ischaemic stroke and Alzheimer's disease (Jo et al., 2014; Nam et al., 2020a). This evidence concerns the gene MAOB and early-onset autosomal dominant Alzheimer disease.