Specifically, sulforaphane (SFN), a well-studied isothiocyanate (17), has been shown to inhibit the action of immune factors which are responsible for upregulation of several proinflammatory cytokines, interleukin-6 (IL-6), IL-8, IL-12, IL-21, and IL-23 (11, 18, 19), which has recently been evaluated as a possible strategy for reducing gut inflammation in humans and mouse models (13, 14, 16). Here, IL6 is linked to inflammatory response.