On the other hand, AMPK activation and subsequent modulation of lipid metabolism was seen in response to Coxsackievirus B3 in primary myocardial cells and after Hepatitis B virus or Dengue virus infection in liver cell lines where AMPK was seen as a negative feedback regulator (35, 36) or even as a supporter of virus replication (37). This evidence concerns the gene PRKAA2 and dengue disease.