KLF5 and cancer: RAD51 overexpression promotes cancer progression.[32] Moreover, tumor cells with high RAD51 expression exhibit PARPi resistance.[33, 34] As the knockdown of KLF5 significantly inhibited the HRR pathway in OC OVCA420 cells, and functional sequencing and analysis of these 18 genes revealed that they contained the core homologous recombination gene RAD51, we speculated that KLF5 might remodel RAD51 transcription.