reported interconnected loops formed by ELF3, KLF5, GATA6, and EHF in esophageal cancer, which promote their expression by interacting with their SEs.[27] The binding of KLF5 to EHF and ELF3 but not GATA6 was also observed in the transcriptional protein complex in our study. The gene discussed is GATA6; the disease is esophageal cancer.