The NLR family pyrin domain containing 3 (NLRP3) inflammasome consists of NLRP3, apoptotic speck like protein (ASC), cleaved caspase‐1, and mature IL‐1β, which were significantly elevated in the AD brain, indicating activation of the NLRP3 inflammasome. The gene discussed is NLRP3; the disease is Alzheimer disease.