A decrease in the expression of antioxidant/phase II detoxifying enzymes, such as UDP-glucurosyltransferase 1A1, NAD(P)H-quinone reductase-1, heme-oxygenase-1, and glutathione S-transferase Mu-1 was linked to the increased severity of colitis in Nrf2-deficient mice (7), while Nrf2 overexpression was reported to improve UC (8). The gene discussed is HMOX1; the disease is colitis.