In RCC, methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) regulated hypoxia-inducible factor (HIF)-2 α mRNA methylation dependent on METTL3, thereby increasing HIF-2 α protein levels and promoting glycolysis (Green et al., 2019). The gene discussed is METTL3; the disease is renal cell carcinoma.