Changes in METTL3 expression were closely associated to the down-regulation of CD4 + T cells, neutrophils, and dendritic cells infiltration level in bladder cancer (Wang et al., 2021b), while positively correlated with naive B cells, CD4+ memory resting T cells, and M1 macrophages number and negatively correlated with regulatory T cells and M2 macrophages number in prostate cancer (Liu et al., 2022c). This evidence concerns the gene CD4 and urinary bladder cancer.