The 3′–5′ exoribonuclease EXOSC10 (also called PM/Scl-100 in humans or Rrp6 in yeast and fly) is part of the multimeric nuclear RNA exosome and interacts with numerous proteins Kowalinski et al., 2016; Januszyk, Liu & Lima, 2011, which has broad clinical importance because it is the target of autoantibodies produced in patients suffering from polymyositis/scleroderma overlap syndrome (Jamin et al., 2017). The gene discussed is EXOSC10; the disease is polymyositis.