ITGB6 and pulmonary fibrosis: To analyze the effect of CPT on the impairment of AEC, we selected integrin subunit beta 6 (ITGB6), which is an epithelial-specific receptor, upregulated in response to epithelial injury and highly expressed in idiopathic pulmonary fibrosis lungs, particularly in AT2 cells in the abnormal epithelial cells called “aberrant basaloid cells”.28