Importantly, S. anginosus, a commensal, was positively correlated with XBP1 (upregulate the transcription of inflammatory cytokines) and TNFSF10 (TNF linked apoptosis inducer) whilst, negatively correlated with the CXCL8 gene which is the primary cytokine involved in neutrophils recruitment at the site of infection. Here, XBP1 is linked to infection.