Apoptosis (BCL6, CTSS, ACTB, TUBA1A, BCL2A1), protein processing in endoplasmic reticulum (HSPA1B, XBP1), and lysosomes (LAPTM5, PSAP, GNS, LITAF) pathways regulated by these genes are responses to infection and injury (Figure 4B-ii). Here, XBP1 is linked to infection.