Besides, we proved that SEMA3B‐AS1 accelerated the transcriptional activation of its sense‐cognate gene SEMA3B, which also played an important inhibitory role in CRC progression by recruiting EP300 to the SEMA3B promoter and increasing acetylation levels of H3K9 at the SEMA3B promoter region. The gene discussed is SEMA3B; the disease is colorectal carcinoma.