The results revealed that SEMA3B was downregulated in most CRC tissues significantly (p < 0.001, Figure S4B), and the RNA levels of SEMA3B‐AS1 and SEMA3B in these samples were positively correlated (r2 = 0.3599, p < 0.001, Figure 3B). Here, SEMA3B is linked to colorectal carcinoma.