Diabetes patients with normo albuminuria may have higher levels of nephrinuria, demonstratingthe usefulness of nephrinuria in diagnosing DN before micro albuminuria develops [22].Since urine nephrin levels appear to rise before micro albuminuria, even if additional research is needed, they are still likelyto be a reliable biomarker of early diabetic kidney impairment. Here, NPHS1 is linked to diabetes mellitus.