Overexpression of YTHDF1 in macrophages could upregulate WW domain containing E3 Ubiquitin protein ligase 1 (WWP1) and thereby alleviate sepsis through promoting NLRP3 ubiquitination and inhibiting caspase-1-dependent pyroptosis (23).However, the systemic investigation of the role of RNA methylation including m1A/m6Am/m5C/m7G/Ψ in sepsis is lacking. The gene discussed is NLRP3; the disease is Sepsis.