These medical events include PFIC3 phenotype (n = 3, one brother of patient 18 and two cousins of patient 4), episode of ICP (seven mothers [families B, D, F, G, W, X, AF], one grandmother [family F] and one aunt [family AE]), cholelithiasis including LPAC syndrome (five parents [families J, U, X, Y, AF], one sister [family P] and 13 additional relatives from 11 families [families F, G, J, L, U, X, Y, AA, AE, AF, AG]), cholangiocarcinoma (n = 2, one father [family C] and one grandfather [family AG]) and hepatocellular carcinoma (n = 1, one uncle [family G]). Here, ABCB4 is linked to cholelithiasis.