In addition, we also observed that BPA exposure up‐regulated the expression of SREBP‐2 by down‐regulating its DNA methylation level in C57BL/6 mice, which led to activation of the hepatic cholesterol synthesis gene HMGCR, resulting in increased hepatic cholesterol synthesis and hepatic steatosis (Li, Zhang, Zou, Mai, et al., 2019). The gene discussed is HMGCR; the disease is fatty liver disease.