SREBF2 and fatty liver disease: In addition, we also observed that BPA exposure up‐regulated the expression of SREBP‐2 by down‐regulating its DNA methylation level in C57BL/6 mice, which led to activation of the hepatic cholesterol synthesis gene HMGCR, resulting in increased hepatic cholesterol synthesis and hepatic steatosis (Li, Zhang, Zou, Mai, et al., 2019).