In line with these researches, we previously showed that curcumin reduced the SREBP‐2 and NPC1L1 expression and cholesterol absorption in the small intestine of HFD‐fed hamsters and apolipoprotein E knockout mice, thereby lowering serum and liver cholesterol levels and preventing HFD‐induced hepatic steatosis and atherosclerosis (Feng et al., 2019; Feng, Zou, Zhang, Li, & Lu, 2017; Zou et al., 2018). This evidence concerns the gene APOE and atherosclerosis.