Apple polyphenol extracts inhibited the proliferation and migration of human breast cancer MDA‐MB‐231 cells by reducing the expression of ubiquitin like with PHD and ring finger domains 1 (UHRF1), matrix metalloproteinase 2 (MMP2), DNA methyltransferase 3 alpha (DNMT3a), and DNMT3b (Song et al., 2017). Here, MMP2 is linked to breast carcinoma.