In conclusion, the results of this study indicate that MOL supplementation markedly decreased the body weight and restored the estrus cycle, significantly increased the expression of Sirt1, FoxO1, PGC‐1α, IGF1, and modulated the sex hormone level and improved insulin resistance, which may be associated with Moringa oleifera leaf supplementation relieves oxidative stress via the Sirt1/FoxO1/ PGC‐1α signaling pathway. Here, PPARGC1A is linked to Insulin resistance.