PPIG and cystitis: CYP-induced cystitis is a reliable, well-validated, and extensively characterized model that reproduces the neurochemical and functional changes and localized bladder inflammation symptoms of IC/BPS (50, 65–67); of particular relevance, mice appear to be more robust to systemic CYP treatment than rats, exhibiting detrusor overactivity, increased urinary frequency, and lower abdominal hyperalgesia without dramatic alterations in physiological state, body temperature, or weight (68), more closely modeling the chronic nature of IC/BPS.