Intravesical administration of ARRY-954 (AR) statistically increased IMI and IV in control (p = 0.01622; p = 0.01633) and acute (p = 0.001935; p = 0.01954) and chronic (p = 0.02549; p = 0.02548) CYP-induced cystitis conditions. Here, PPIG is linked to cystitis.