Increased hip fractures have been most extensively studied, with less consistent evidence for nonhip fractures.(38) Peripheral fractures, particularly at the wrist and lower leg (foot, ankle), also appear to be more common in T2D, though it is unclear if this risk is only in certain individuals with T2D (e.g., treated with insulin, comorbid diabetic microvascular complication (22, 41, 42)). Here, INS is linked to type 2 diabetes mellitus.