We selected the gene SETD2, which has been reported to be related to neuropsychiatric diseases, such as autism [42] and Sotos-like syndrome [43], and its 2 representative de novo missense mutations, i.e., Y1666C and L1815T as well as a somatic missense mutation, i.e., S1624C reported from autism patients [42,44,45] for experimental validation. Here, SETD2 is linked to autism.