However, further studies should aim to clarify the relevance and function of S100A8/A9 and its receptors in cancers or other serious disorders, such as the balance of promotion and inhibition to cancers, new effects on oncogenesis, crosstalk of different receptors and concrete mechanism, correlation with tumor microenvironment, synergistic or antagonism cooperation with inflammatory factors, as well as discovery of feasible drug targets, which could open a new door leading to a brand new era when cancer may be disappearing. The gene discussed is S100A8; the disease is cancer.