In addition to these functions, S100A8/A9 also participates in procoagulant platelet formation (Colicchia et al., 2022), intestinal microbiota development (Willers et al., 2020), autophagy-dependent ferroptosis (Tao et al., 2022), anemia, and bone marrow failure (Giudice et al., 2019), most of which are closely related to immunity and inflammation, indicating that S100A8/A9 may serve as a biomarker and therapeutic target in this field. This evidence concerns the gene S100A8 and anemia (phenotype).