S100A8 and cancer: As a significant inflammatory mediator, S100A8/A9 extensively influences granulocyte and monocyte migration, antibiosis, inflammatory propagation, macrophage activation, and cytostatic effect (Kerkhoff et al., 1998), playing prominent and complicated roles in myocardial infarction (Cai et al., 2020), cancer (Ghavami et al., 2009), coronavirus disease 2019 (Guo et al., 2021), tuberculosis (Scott et al., 2020), psoriasis (Matsunaga et al., 2021), and systemic lupus erythematosus (Lood et al., 2016).