CD274 and interstitial lung disease: Drug factors: 1type of drugs; it has been reported that patients receiving targeted and ICIs therapy have a higher incidence of DILD and a worse prognosis than cytotoxic drugs (Nishino et al., 2017), and the incidence of ILD caused by PD-1 inhibitors is higher than that caused by programmed death ligand-1 (PD-L1) inhibitor.