SOCS3 and obesity due to melanocortin 4 receptor deficiency: IL-6 plays a particularly significant role in conditions like obesity, leading to elevated levels of cytokine signaling inhibitor proteins SOCS1 and SOCS3, which are primarily found in insulin-sensitive peripheral tissues like white adipose tissue, liver, and muscle, At the molecular level, the increase in SOCS1 and SOCS3 results in impairment of the insulin signaling pathway through binding to IRS-1 and IRS-2 (Shi et al., 2016).