The levels of SPAP and mPAP in the PAH-CHD-H group were significantly higher than those of the PAH-CHD-M and PAH-CHD-L groups (p < 0.05), but there was no statistically significant difference in SPAP between the PAH-CHD-M and PAH-CHD-L groups (p > 0.05). The gene discussed is PDZK1IP1; the disease is pulmonary arterial hypertension.