The clinical treatment of AR-HIES patients must include supportive care such as emollient creams, antihistamines, and antibiotics in the presence of infection as they navigate living with its manifestations of recurrent cutaneous infections, allergies, eosinophilia, elevated IgE levels, and the dermatological manifestations of eczema, dermatitis, and pruritus. Here, IGHE is linked to Allergy.