Excessive cell death or cell turnover can also cause hyperuricemia due to an increase in serum purine [7]. Uric acid may increase blood pressure (BP) through oxidative stress, nitric oxide reduction, renin-angiotensin system activation, endothelial inflammation, vascular smooth muscle proliferation, and insulin resistance [4,6]. In this review article, we summarize the relevant studies that show the association between elevated sUA concentration and new-onset HTN. The gene discussed is REN; the disease is hyperuricemia.