REN and hypertensive disorder: High sUA can lead to HTN through various mechanisms, including inflammation in the kidney and endothelium, activation of the renin-angiotensin system, depletion of nitric oxide, smooth muscle cell proliferation, superoxide generation, mitochondrial dysfunction, and activation of polyol pathway. A direct and dose-dependent association of uric acid level on increased SBP and DBP in both males and females has been established.