INS and hypertensive disorder: Furthermore, after additional adjustments for estimated glomerular filtration rate (eGFR), levels of total cholesterol, triglycerides, insulin, homocysteine, and soluble intercellular adhesion molecule-1 (sICAM-1), it was found that every 1 mg/dL increase in uric acid level was associated with a 1.25-fold increase in odds of incident HTN. The OR in the highest quartile when compared with the lowest quartile of uric acid level was 1.89 [17].