IGF1 and breast cancer: As demonstrated in the MCF-7 breast cancer cell line, miR-206 can regulate an estrogenic response through EGFR signaling (Adams et al., 2009), as well as inhibit IGF-1 protein expression, and low expression of miR-206 might contribute to endometrium angiogenesis during embryo implantation as evidenced in porcine endometrium (Hong et al., 2019).