After microglia TLR3 and TLR9 are co-activated, microglia shift to an anti-tumor phenotype and enhance migratory activity to accumulate in glioma tissue, which in turn inhibits glioma cell function by releasing cytokines or directly kills glioma cells by enhancing phagocytic activity of microglia (143). This evidence concerns the gene TLR3 and central nervous system cancer.