WT1 expression is notably elevated in EVs isolated from the CSF of patients with malignant glioma, and glioma-derived EVs with WT1 promote tumor progression by suppressing the expression of the Thbs1 gene(Thbs1 is a negative regulator) and TSP-1 (TSP-1 has anti-tumor angiogenic properties) production in microglia (186). This evidence concerns the gene THBS1 and central nervous system cancer.