In vitro experiments demonstrate that glioma cell-derived Wnt3a triggers the activation of the Wnt/β-catenin pathway in microglia, induces them to express ARG-1 and STI1, shifts them to the M2 phenotype, enhances tumor infiltration, invasion, growth and the crosstalk between microglia and gliomas (87). This evidence concerns the gene STIP1 and glioma.