The interaction between microglia and tumor cells is a crucial factor that initiates the secretion of IL-6, which leads to hyperpermeability of brain endothelial cells through activation of the JAK (Janus Kinase)/STAT3 pathway, ultimately leading to enhanced BBB permeability, and BBB damage is a critical step in the progression of brain tumors (75). The gene discussed is STAT3; the disease is neoplasm.