Dahuang Zhechong Pill (DHZCP) significantly reduced serum exosomal CC chemokine ligand-2 (CCL2) levels and its receptor CCR2, which in exosomes triggers macrophage recruitment and converts M1/M2 macrophages in the liver to the M2 phenotype, and DHZCP modulated the pathway of CCL2 in exosomes reversing the pro-tumor polarization of macrophages (62). This evidence concerns the gene CCL2 and neoplasm.