PTGS2 and neoplasm: The involvement of tumor-derived exosomes in the induction of inflammatory PMN formation in distant organs to promote metastasis has been supported, as cell migration-inducing and hyaluronan binding protein (CEMIP) of lung tumor origin can induce pro-inflammatory vascular ecotopes to promote metastasis by upregulating cytokines prostaglandin endoperoxide synthase 2(PTGS2), tumor necrosis factor(TNF) and chemokine (C-C Motif) ligand(CCL)/chemokine (C-X-C motif) ligand(CXCL) cytokines (23).