Heat shock proteins are a key pathway for TLR initiation, and kaempferol, a potent flavonoid compound derived from cinnamon leaves, can reduce exosome secretion from cancer cells by regulating the protein expression of heat shock protein HSP 90-α (HSP90AA1), heat shock protein HSP 90-β (HSP90AB1), and ubiquitin-like modifier activator enzyme 1 (UBA1), vacuolar sorting protein 4(VPS4A) are important targets among them (58). This evidence concerns the gene VPS4A and cancer.