CD8A and lung cancer: DC, as one of the most functional antigen-presenting cells, is necessary for lung cancer cells to achieve immune escape by remotely controlling DC the presence of EGFR in lung cancer exosomes induces tolerogenic DCs, which in turn induce the production of tumor antigen-specific regulatory T cells (Tregs), which suppress tumor antigen-specific CD8 T cells and induce immune tolerance in lung cancer patients (32).