AML with NPM1 mutations is most seen in 27% of patients and is frequently co-mutated with DNMT3A, FLT3-ITD, TET2, and PTPN11. AML with mutated chromatin, RNA splicing genes, or both were detected in 15% of AML patients and frequently co-mutated genes were RUNX1, SRSF2, MLL, DNMT3A, ASXL1, STAG2, NRAS, TET2, and FLT3-ITD. The gene discussed is NPM1; the disease is acute myeloid leukemia.