Like our previous study, TI administration generated a significant, transient increase in IL6 levels in tumor (105 pg/mL 4 hours after TI vs. 30 pg/mL baseline, P = 0.015; Supplementary Fig. S2), as well as significant increases in tumor neutrophils (7.48% 4 hours after TI vs. 2.34% at baseline, P = 0.027; 6.12% 19 hours after TI, P = 0.003; Supplementary Fig. S2). The gene discussed is IL6; the disease is neoplasm.