In psoriasis, miR-215 is reported to be downregulated in the skin lesion tissues in humans and mouse models, with the functional role validated in a keratinocyte-specific study, wherein miR-215 is shown to target DYRK1A and dysregulate keratinocyte proliferation via EGFR signaling (6, 52, 81). The gene discussed is DYRK1A; the disease is psoriasis.