APOE and Cognitive impairment: Following the stratification of sex and age, two major interfering factors of cognitive performance,19, 20 we found that female (p = .0007) but not male (p = .39) ε4 carriers had lower MMSE scores than their ε3 counterparts (Figure S1A), indicating female patients may be more vulnerable than male patients to ApoE ε4 induced cognitive impairment.