Activation of GSK‐3β was significant correlated with ε4 (p < .05) but not ε2 (p > .05) in linear regression analysis without (Table 4,model 1) or with (Table 4, model 2 and 3) adjustment by age, sex, diabetes duration, HbA1c, FPG, history of hypertension, hyperlipidemia, CHD, and diabetic complications. This evidence concerns the gene GSK3B and hypertensive disorder.