Besides inducing PTEN expression, pioglitazone also intensified the tumour‐killing effect of arsenic trioxide (ATO) in leukaemia via the suppression of PI3K/AKT pathway,113 and mTOR inhibitor rapamycin has been shown to enhance the effects of rosiglitazone in inhibiting non‐small cell lung carcinoma (NSCLC) cell proliferation in vivo.111. Here, PTEN is linked to neoplasm.