Jiali Li et al. presented that METTL3 could promote cell proliferation, migration and invasion and upregulate the expression of COL12A1 in esophageal squamous cell carcinoma (ESCC) cell lines; besides, COL12A1 could restrain siMETTL3-mediated inhibition of proliferation, migration and invasion [78]. This evidence concerns the gene METTL3 and esophageal squamous cell carcinoma.