The top 5 upregulated genes, with p value < 0.0005, i.e., -log10(p value) > 3, were mostly involved in metabolic processes: Akr1c19 (oxydoreductase activity), Inpp4a (hydrolase activity), Tmie and Stfa2 (involved in protein trafficking), and Klhl38 (involved in NSCLC via the Akt signaling pathway). The gene discussed is KLHL38; the disease is non-small cell lung carcinoma.