The top 5 downregulated genes with p value < 1.10−5, i.e., -log10(p value) > 5 in the ATO group, were Abca13 (having a role in the innate immune system), Alox5ap (an immune-modulating lipid mediator involved in immune response and regulation), Rab37 (metastasis suppressor involved in lung cancer), Pglyrp1 (involved in humoral immune response), and Adam23 (a metalloprotease involved in cell adhesion) (Fig. 5A). The gene discussed is ALOX5AP; the disease is lung carcinoma.