Conversely Wilson et al., in the longitudinal ROS and MAP studies which used CES-D to monitor depressive symptoms, found that neither amyloid nor tau load measured by immunohistochemistry in 8 areas of brain from 582 individuals who had donated their brains (2/3 of whom had developed MCI or dementia) was related to depressive symptoms during follow-up [56]. The gene discussed is MAPT; the disease is dementia.