In addition, CDKN1C and DLK1 appear to be hormonally regulated, with the former decreasing after expose to estradiol in endometrial cancer cells [47], while the latter decreasing after treatment with estradiol in girls with anorexia nervosa or human uterine leiomyoma cells [48, 49]. This evidence concerns the gene CDKN1C and Uterine leiomyoma.