A second gene locus that yielded significant associations was BIN1. As for APOE-ε4, the BIN1 lead variant was associated with the risk of sole AD (AD+LB–) and AD+LB+ co-pathology, but not sole LB (AD–LB+) when compared to no pathology (AD–LB–). The gene discussed is APOE; the disease is Alzheimer disease.