APOE and Alzheimer disease: Another gene locus that yielded significant associations was BIN1. Like APOE-ε4, we observed that rs4663105 on the BIN1 locus was associated with risk of AD+LB– pathology compared to AD–LB– pathology (OR = 1.40, 95% CI = 1.26–1.56, P = 6.5 × 10−10) and risk of AD+LB+ pathology compared to AD–LB– pathology (OR = 1.53, 95% CI = 1.35–1.75, P = 1.