APOE and Alzheimer disease: [45] found that APOE-ε4 was associated with cortical LB co-pathology (cortical LB pathology accompanied by an amyloidopathy, tauopathy, or TDP-43 proteinopathy) compared to sole LB pathology; however, APOE-ε4 was not associated with AD-LB co-pathology compared to sole AD pathology [45].