In particular, by using genome-wide association studies, autophagy-related genes like ATG5 were found to be associated with disease susceptibility in SLE, while risk alleles of variants locating in PRDM1-ATG5 gene region were positively correlated with ATG5 expression in B cells from lupus patients [46]. The gene discussed is PRDM1; the disease is systemic lupus erythematosus.