Up-regulated expression of SNHG16, TLR4 and TRAF6, but not NEAT1, was identified in PBNs from SLE patients in comparison with those from HC (Fig. 5a, d, g, Additional file 1: S4e, for SNHG16, p = 0.045, for TLR4, p = 0.002, for TRAF6, p = 0.026). This evidence concerns the gene TLR4 and systemic lupus erythematosus.