TRAF6 and systemic lupus erythematosus: In our previous studies analyzing the SLE-associated AH lungs [24], down-regulated miR-146a expression was shown to enhance apoptosis and neutrophil extracellular traps (NETs) formation through reversing its targeting effects on TAF9b, a p53 co-activator/stabilizer, and TRAF6, a signal transducer activating IL-8 production, respectively.