Since the expression of lncRNAs is closely regulated by cytokine milieu, such inconsistent findings might be related to distinct cytokine profiles in different SLE target organs, proinflammatory cytokines IL-6/IL-8 in the lungs versus Th1 cytokines IFN-γ/IL-2 in the kidneys [24]. This evidence concerns the gene CXCL8 and systemic lupus erythematosus.