Previous studies [34] have found that the transmembrane protein 71 (TMEM71) is upregulated in GSCs and Temozolomide-resistant cells, and TMEM71 expression correlated positively with the degree of glioma malignancy, which might be mediated by involvement in tumor immune and inflammatory responses, cell proliferation, cell migration, chemotaxis, and response to drugs. This evidence concerns the gene TMEM71 and central nervous system cancer.