Previous studies [34] have found that the transmembrane protein 71 (TMEM71) is upregulated in GSCs and Temozolomide-resistant cells, and TMEM71 expression correlated positively with the degree of glioma malignancy, which might be mediated by involvement in tumor immune and inflammatory responses, cell proliferation, cell migration, chemotaxis, and response to drugs. The gene discussed is TMEM71; the disease is glioma.