MGMT and central nervous system cancer: Univariate Cox regression analysis showed that age, IDH (encoding isocitrate dehydrogenase) mutation status, 1p19q codeletion status, O6-methylguanine (O6-MeG)-DNA methyltransferase (MGMT) status, and RRPRS risk scores correlated significantly with the PFS of patients with glioma (Table 2).