This was supported by the upregulation of the NF-kB inhibitor genes NFKBIA and NFKBIZ, the AP-1 transcription factor complex genes FOS, JUN, FOSB and JUNB as well as other NF-kB target genes such as TNFAIP3, RELB, NR4A2, DUSP1 and CD69 in response to infection. The gene discussed is JUNB; the disease is infection.