Here, based on published single-cell transcriptomic data from two large COVID-19 cohorts, the Oxford COVID-19 Multi-omics Blood Atlas (COMBAT) [5] and the INCOV [6] cohorts, we show that a core set of co-regulated genes from the IL2-AIS is modulated in the opposite direction in blood T, B and NK cells as well as in monocytes of COVID-19 patients. Here, IL2 is linked to COVID-19.