After adjusting various confounding factors, multiple logistic regression presented associated factors of ESS including HbA1c (OR = 1.112, P = 0.040, 95%CI 1.005 ~ 1.231), CO2CP (OR = 0.933, P = 0.007, 95%CI 0.888 ~ 0.981), albumin (OR = 0.866, P < 0.001, 95%CI 0.814 ~ 0.921), WBC (OR = 1.146, P = 0.002, 95%CI 1.052 ~ 1.248), and co-infection (OR = 1.929, P = 0.031, 95%CI 1.063 ~ 3.500) (Table 4). This evidence concerns the gene ALB and coinfection.