Although the high number of RBM CD4 + T-cells in ACO showed a statistical significance as compared to asthma, COPD-ES (P < 0.05), CS (P < 0.05), and NLFS (P < 0.05), it should be borne in mind that CD4 + T-cells in the RBM were noted only in 4 ACO patients, 1 asthma patients, and in 1 NLFS. The gene discussed is CD4; the disease is chronic obstructive pulmonary disease.